Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study.

ABSTRACT:

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Background

Recent studies implicate individual differences in regulatory focus as contributing to self-regulatory dysfunction, particularly not responding to positive outcomes. How such individual differences emerge, however, is unclear. We conducted a proof-of-concept study to examine the moderating effects of genetically driven variation in dopamine signaling, a key modulator of neural reward circuits, on the association between regulatory focus and reward cue responsiveness.

Method

Healthy Caucasians (N=59) completed a measure of chronic regulatory focus and a probabilistic reward task. A common functional genetic polymorphism impacting prefrontal dopamine signaling (COMT rs4680) was evaluated.

Results

Response bias, the participants' propensity

SUBMITTER: Goetz EL 

PROVIDER: S-EPMC3570330 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature