Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism.

ABSTRACT:

Unlabelled

Background

The mitochondrial genome (mtDNA) is particularly susceptible to damage mediated by reactive oxygen species (ROS). Although elevated ROS production and elevated biomarkers of oxidative stress have been found in tissues from children with autism spectrum disorders, evidence for damage to mtDNA is lacking.

Findings

mtDNA deletions were evaluated in peripheral blood monocytic cells (PBMC) isolated from 2-5 year old children with full autism (AU; n = 67), and typically developing children (TD; n = 46) and their parents enrolled in the CHildhood Autism Risk from Genes and Environment study (CHARGE) at University of California Davis. Sequence variants were evaluated in mtDNA segments from AU and TD children (n = 10; each) and their mothers representing

SUBMITTER: Napoli E 

PROVIDER: S-EPMC3570390 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature