Identification of CpG islands in DNA sequences using statistically optimal null filters.

ABSTRACT: : CpG dinucleotide clusters also referred to as CpG islands (CGIs) are usually located in the promoter regions of genes in a deoxyribonucleic acid (DNA) sequence. CGIs play a crucial role in gene expression and cell differentiation, as such, they are normally used as gene markers. The earlier CGI identification methods used the rich CpG dinucleotide content in CGIs, as a characteristic measure to identify the locations of CGIs. The fact, that the probability of nucleotide G following nucleotide C in a CGI is greater as compared to a non-CGI, is employed by some of the recent methods. These methods use the difference in transition probabilities between subsequent nucleotides to distinguish between a CGI from a non-CGI. These transition probabilities vary with the data being analyzed and sev

SUBMITTER: Kakumani R 

PROVIDER: S-EPMC3570435 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature