P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.

ABSTRACT:

Rationale

The function of the P2X(7) nucleotide receptor protects against exacerbation in people with mild-intermittent asthma during viral illnesses, but the impact of disease severity and maintenance therapy has not been studied.

Objectives

To evaluate the association between P2X(7), asthma exacerbations, and incomplete symptom control in a more diverse population.

Methods

A matched P2RX7 genetic case-control was performed with samples from Asthma Clinical Research Network trial participants enrolled before July 2006, and P2X(7) pore activity was determined in whole blood samples as an ancillary study to two trials completed subsequently.

Measurements and main results

A total of 187 exacerbations were studied in 742 subjects, and the change in asthma symptom

SUBMITTER: Denlinger LC 

PROVIDER: S-EPMC3570642 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature