Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype.

ABSTRACT:

Rationale

Asthma is a heterogeneous lung disorder characterized by airway inflammation and airway dysfunction, manifesting as hyperresponsiveness and obstruction. Glutathione S-transferase M1 (GSTM1) is a multifunctional phase II enzyme and regulator of stress-activated cellular signaling relevant to asthma pathobiology. A common homozygous deletion polymorphism of the GSTM1 gene eliminates enzyme activity.

Objectives

To determine the effect of GSTM1 on airway inflammation and reactivity in adults with established atopic asthma in vivo.

Methods

Nineteen GSTM1 wild-type and eighteen GSTM1-null individuals with mild atopic asthma underwent methacholine and inhaled allergen challenges, and endobronchial allergen provocations through a bronchoscope.

Measurements and ma

SUBMITTER: Hoskins A 

PROVIDER: S-EPMC3570644 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature