Transcriptional changes in the transition from vegetative cells to asexual development in the model fungus Aspergillus nidulans.

ABSTRACT: Morphogenesis encompasses programmed changes in gene expression that lead to the development of specialized cell types. In the model fungus Aspergillus nidulans, asexual development involves the formation of characteristic cell types, collectively known as the conidiophore. With the aim of determining the transcriptional changes that occur upon induction of asexual development, we have applied massive mRNA sequencing to compare the expression pattern of 19-h-old submerged vegetative cells (hyphae) with that of similar hyphae after exposure to the air for 5 h. We found that the expression of 2,222 (20.3%) of the predicted 10,943 A. nidulans transcripts was significantly modified after air exposure, 2,035 being downregulated and 187 upregulated. The activation during this transition of genes

SUBMITTER: Garzia A 

PROVIDER: S-EPMC3571305 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature