Ontology highlight
ABSTRACT:
SUBMITTER: Li JZ
PROVIDER: S-EPMC3571444 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20121221 6
Drug-resistant human immunodeficiency virus type 1 (HIV-1) minority variants increase the risk of virologic failure for first-line nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens. We performed a pooled analysis to evaluate the relationship between NNRTI-resistant minority variants and the likelihood and types of resistance mutations detected at virologic failure. In multivariable logistic regression analysis, higher NNRTI minority variant copy numbers, non-white race, and ne ...[more]