Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation.

ABSTRACT:

Study objectives

Besides their well-established role in circadian rhythms, our findings that the forebrain expression of the clock-genes Per2 and Dbp increases and decreases, respectively, in relation to time spent awake suggest they also play a role in the homeostatic aspect of sleep regulation. Here, we determined whether time of day modulates the effects of elevated sleep pressure on clock-gene expression. Time of day effects were assessed also for recognized electrophysiological (EEG delta power) and molecular (Homer1a) markers of sleep homeostasis.

Design

EEG and qPCR data were obtained for baseline and recovery from 6-h sleep deprivation starting at ZT0, -6, -12, or -18.

Setting

Mouse sleep laboratory.

Participants

Male mice.

Interventions

Sleep de

SUBMITTER: Curie T 

PROVIDER: S-EPMC3571738 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature