In-line filtration minimizes organ dysfunction: new aspects from a prospective, randomized, controlled trial.

ABSTRACT:

Background

Infused particles induce thrombogenesis, impair microcirculation and modulate immune response. We have previously shown in critically ill children, that particle-retentive in-line filtration reduced the overall complication rate of severe events, length of stay and duration of mechanical ventilation. We now evaluated the influence of in-line filtration on different organ function and thereby elucidated the potential underlying pathophysiological effects of particle infusion.

Methods

In this single-centre, prospective, randomized controlled trial 807 critically ill children were assigned to either control (n = 406) or filter group (n = 401), the latter receiving in-line filtration for complete infusion therapy. Both groups were compared regarding the differences of

SUBMITTER: Boehne M 

PROVIDER: S-EPMC3571889 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature