The effect of blood storage age on treatment of lactic acidosis by transfusion in children with severe malarial anaemia: a pilot, randomized, controlled trial.

ABSTRACT:

Background

Severe malarial anaemia requiring blood transfusion is a life-threatening condition affecting millions of children in sub-Saharan Africa. Up to 40% of children with severe malarial anaemia have associated lactic acidosis. Lactic acidosis in these children is strongly associated with fatal outcomes and is corrected by blood transfusion. However, it is not known whether the storage age of blood for transfusion affects resolution of lactic acidosis. The objective of this pilot study was to evaluate the effect of blood storage age on resolution of lactic acidosis in children with severe malarial anaemia and demonstrate feasibility of conducting a large trial.

Methods

Children aged six to 59 months admitted to Acute Care Unit of Mulago Hospital (Kampala, Uganda) with s

SUBMITTER: Dhabangi A 

PROVIDER: S-EPMC3571913 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature