Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior.

ABSTRACT:

Background

Colon cancer patients with the same stage show diverse clinical behavior due to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray expression patterns, to analyze whether the molecular classification correlated with the histopathological stages or other clinical parameters and to study differences in the survival.

Methods

Hierarchical clustering was performed for class discovery in 88 colon tumors (stages I to IV). Pathways analysis and correlations between clinical parameters and our classification were analyzed. Tumor subtypes were validated using an external set of 78 patients. A 167 gene signature associated to the main subtype was generated using the 3-Nearest-Neighbor method. Coincidences with other prognostic predictors

SUBMITTER: Perez-Villamil B 

PROVIDER: S-EPMC3571914 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature