Dietary composition regulates Drosophila mobility and cardiac physiology.

ABSTRACT: The impact of dietary composition on exercise capacity is a subject of intense study in both humans and model organisms. Interactions between diet and genetics are a crucial component of optimized dietary design. However, the genetic factors governing exercise response are still not well understood. The recent development of invertebrate models for endurance exercise is likely to facilitate study designs examining the conserved interactions between diet, exercise and genetics. As a first step, we used the Drosophila model to describe the effects of varying dietary composition on several physiological indices, including fatigue tolerance and climbing speed, cardiac performance, lipid storage and autophagy. We found that flies of two divergent genetic backgrounds optimize endurance and cardi

SUBMITTER: Bazzell B 

PROVIDER: S-EPMC3571989 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature