The N-terminal intrinsically disordered domain of Mgm101p is localized to the mitochondrial nucleoid.

ABSTRACT: The mitochondrial genome maintenance gene, MGM101, is essential for yeasts that depend on mitochondrial DNA replication. Previously, in Saccharomyces cerevisiae, it has been found that the carboxy-terminal two-thirds of Mgm101p has a functional core. Furthermore, there is a high level of amino acid sequence conservation in this region from widely diverse species. By contrast, the amino-terminal region, that is also essential for function, does not have recognizable conservation. Using a bioinformatic approach we find that the functional core from yeast and a corresponding region of Mgm101p from the coral Acropora millepora have an ordered structure, while the N-terminal domains of sequences from yeast and coral are predicted to be disordered. To examine whether ordered and disordered domai

SUBMITTER: Hayward DC 

PROVIDER: S-EPMC3572067 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature