Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece.

ABSTRACT:

Objective

To determine the extent to which the risk for incident coronary heart disease (CHD) increases in relation to a genetic risk score (GRS) that additively integrates the influence of high-risk alleles in nine documented single nucleotide polymorphisms (SNPs) for CHD, and to examine whether this GRS also predicts incident stroke.

Methods

Genotypes at nine CHD-relevant SNPs were determined in 494 cases of incident CHD, 320 cases of incident stroke and 1345 unaffected controls drawn from the population-based Greek component of the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. An additive GRS was calculated for each study participant by adding one unit for the presence of each high-risk allele multiplied by the estimated effect size of that a

SUBMITTER: Yiannakouris N 

PROVIDER: S-EPMC3572363 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature