An in vivo screen of secreted proteins identifies adiponectin as a regulator of murine cutaneous wound healing.

ABSTRACT: Skin wounds comprise a serious medical issue for which few pharmacological interventions are available. Moreover, the inflammatory, angiogenic, and proliferative facets of a typical response to a wound each have broader relevance in other pathological conditions. Here we describe a genomics-driven approach to identify secreted proteins that modulate wound healing in a mouse ear punch model. We show that adiponectin, when injected into the wound edge, accelerates wound healing. Notably, adiponectin injection causes upregulation of keratin gene transcripts within hours of treatment, and subsequently promotes collagen organization, formation of pilosebaceous units, and proliferation of cells in the basal epithelial cell layer and pilosebaceous units of healing tissue. The globular domain of a

SUBMITTER: Salathia NS 

PROVIDER: S-EPMC3572451 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature