Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem.

ABSTRACT:

Background and purpose

Prokineticin 2 (PK2) has recently been shown to acutely reduce food intake in rodents. We aimed to determine the CNS sites and receptors that mediate the anorectic effects of peripherally administered PK2 and its chronic effects on glucose and energy homeostasis.

Experimental approach

We investigated neuronal activation following i.p. administration of PK2 using c-Fos-like immunoreactivity (CFL-IR). The anorectic effect of PK2 was examined in mice with targeted deletion of either prokineticin receptor 1 (PKR1) or prokineticin receptor 2 (PKR2), and in wild-type mice following administration of the PKR1 antagonist, PC1. The effect of IP PK2 administration on glucose homeostasis was investigated. Finally, the effect of long-term administration of PK2 on

SUBMITTER: Beale K 

PROVIDER: S-EPMC3572566 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature