An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.

ABSTRACT:

Background and purpose

The success of antibody-drug conjugates (ADCs) depends on the therapeutic window rendered by the differential expression between normal and pathological tissues. The ability to identify and visualize target expression in normal tissues could reveal causes for target-mediated clearance observed in pharmacokinetic characterization. TENB2 is a prostate cancer target associated with the progression of poorly differentiated and androgen-independent tumour types, and ADCs specific for TENB2 are candidate therapeutics. The objective of this study was to locate antigen expression of TENB2 in normal tissues, thereby elucidating the underlying causes of target-mediated clearance.

Experimental approach

A series of pharmacokinetics, tissue distribution and mass ba

SUBMITTER: Boswell CA 

PROVIDER: S-EPMC3572570 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature