Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer.

ABSTRACT: Signaling inputs from multiple pathways are essential for the establishment of distinct cell and tissue types in the embryo. Therefore, multiple signals must be integrated to activate gene expression and confer cell fate, but little is known about how this occurs at the level of target gene promoters. During early embryogenesis, Wnt and Nodal signals are required for formation of the Spemann organizer, which is essential for germ layer patterning and axis formation. Signaling by both Wnt and Nodal pathways is required for the expression of multiple organizer genes, suggesting that integration of these signals is required for organizer formation. Here, we demonstrate transcriptional cooperation between the Wnt and Nodal pathways in the activation of the organizer genes Goosecoid (Gsc), Cerb

SUBMITTER: Reid CD 

PROVIDER: S-EPMC3572767 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature