Indigenous American ancestry is associated with arsenic methylation efficiency in an admixed population of northwest Mexico.

ABSTRACT: Many studies provide evidence relating lower human arsenic (As) methylation efficiency, represented by high percent urinary monomethylarsonic acid (MMA(V)), with several As-induced diseases, possibly due to the fact that MMA(V) serves as a proxy for MMA(III), the most toxic As metabolite. Some epidemiological studies suggested that indigenous Americans (AME) methylate As more efficiently; however, data supporting this have been equivocal. The aim of this study was to characterize the association between AME ancestry and As methylation efficiency using a panel of ancestry informative genetic markers to determine individual ancestry proportions in an admixed population (composed of two or more isolated ancestral populations) of 746 individuals environmentally exposed to As in northwest Mexic

SUBMITTER: Gomez-Rubio P 

PROVIDER: S-EPMC3572940 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature