Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain.

ABSTRACT: Neogenin has been implicated in a variety of developmental processes such as neurogenesis, neuronal differentiation, apoptosis, migration and axon guidance. Binding of repulsive guidance molecules (RGMs) to Neogenin inhibits axon outgrowth of different neuronal populations. This effect requires Neogenin to interact with co-receptors of the uncoordinated locomotion-5 (Unc5) family to activate downstream Rho signaling. Although previous studies have reported RGM, Neogenin, and/or Unc5 expression, a systematic comparison of RGM and Neogenin expression in the developing nervous system is lacking, especially at later developmental stages. Furthermore, information on RGM and Neogenin expression at the protein level is limited. To fill this void and to gain further insight into the role of RGM-Ne

SUBMITTER: van den Heuvel DM 

PROVIDER: S-EPMC3573027 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature