Oil palm phenolics attenuate changes caused by an atherogenic diet in mice.

ABSTRACT:

Background

Water-soluble phenolics from the oil palm possess significant biological properties.

Purpose

In this study, we aimed to discover the role of oil palm phenolics (OPP) in influencing the gene expression changes caused by an atherogenic diet in mice.

Methods

We fed mice with either a low-fat normal diet (14.6 % kcal/kcal fat) with distilled water, or a high-fat atherogenic diet (40.5 % kcal/kcal fat) containing cholesterol. The latter group was given either distilled water or OPP. We harvested major organs such as livers, spleens and hearts for microarray gene expression profiling analysis. We determined how OPP changed the gene expression profiles caused by the atherogenic diet. In addition to gene expression studies, we carried out physiological observations

SUBMITTER: Leow SS 

PROVIDER: S-EPMC3573186 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature