Adaptive clustering and adaptive weighting methods to detect disease associated rare variants.

ABSTRACT: Current statistical methods to test association between rare variants and phenotypes are essentially the group-wise methods that collapse or aggregate all variants in a predefined group into a single variant. Comparing with the variant-by-variant methods, the group-wise methods have their advantages. However, two factors may affect the power of these methods. One is that some of the causal variants may be protective. When both risk and protective variants are presented, it will lose power by collapsing or aggregating all variants because the effects of risk and protective variants will counteract each other. The other is that not all variants in the group are causal; rather, a large proportion is believed to be neutral. When a large proportion of variants are neutral, collapsing or aggrega

SUBMITTER: Sha Q 

PROVIDER: S-EPMC3573192 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature