Basal ganglia-cortical interactions in Parkinsonian patients.

ABSTRACT: Parkinson's disease is a common and debilitating condition, caused by aberrant activity in a complex basal ganglia-thalamocortical circuit. Therapeutic advances rely on characterising interactions in this circuit. However, recording electrophysiological responses over the entire circuit is impractical. Dynamic causal modelling offers large-scale models of predictive value based on a limited or partial sampling of complex networks. Using dynamic causal modelling, we determined the network changes underlying the pathological excess of beta oscillations that characterise the Parkinsonian state. We modelled data from five patients undergoing surgery for deep brain stimulation of more than one target. We found that connections to and from the subthalamic nucleus were strengthened and promoted b

SUBMITTER: Marreiros AC 

PROVIDER: S-EPMC3573233 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature