Kdo hydrolase is required for Francisella tularensis virulence and evasion of TLR2-mediated innate immunity.

ABSTRACT:

Unlabelled

The highly virulent Francisella tularensis subsp. tularensis has been classified as a category A bioterrorism agent. A live vaccine strain (LVS) has been developed but remains unlicensed in the United States because of an incomplete understanding of its attenuation. Lipopolysaccharide (LPS) modification is a common strategy employed by bacterial pathogens to avoid innate immunity. A novel modification enzyme has recently been identified in F. tularensis and Helicobacter pylori. This enzyme, a two-component Kdo (3-deoxy-d-manno-octulosonic acid) hydrolase, catalyzes the removal of a side chain Kdo sugar from LPS precursors. The biological significance of this modification has not yet been studied. To address the role of the two-component Kdo hydrolase KdhAB in F. tularens

SUBMITTER: Okan NA 

PROVIDER: S-EPMC3573668 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature