Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities.

ABSTRACT: Enniatins are cyclohexadepsipeptides isolated largely from Fusarium species of fungi, although they have been isolated from other genera, such as Verticillium and Halosarpheia. They were first described over 60 years ago, and their range of biological activities, including antiinsectan, antifungal, antibiotic and cytotoxic, drives contemporary interest. To date, 29 enniatins have been isolated and characterized, either as a single compound or mixtures of inseparable homologs. Structurally, these depsipeptides are biosynthesized by a multifunctional enzyme, termed enniatin synthetase, and are composed of six residues that alternate between N-methyl amino acids and hydroxy acids. Their structure elucidation can be challenging, particularly for enniatins isolated as inseparable homologs; howe

SUBMITTER: Sy-Cordero AA 

PROVIDER: S-EPMC3573854 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature