Transferability and fine mapping of genome-wide associated loci for lipids in African Americans.

ABSTRACT:

Background

A recent, large genome-wide association study (GWAS) of European ancestry individuals has identified multiple genetic variants influencing serum lipids. Studies of the transferability of these associations to African Americans remain few, an important limitation given interethnic differences in serum lipids and the disproportionate burden of lipid-associated metabolic diseases among African Americans.

Methods

We attempted to evaluate the transferability of 95 lipid-associated loci recently identified in European ancestry individuals to 887 non-diabetic, unrelated African Americans from a population-based sample in the Washington, DC area. Additionally, we took advantage of the generally reduced linkage disequilibrium among African ancestry populations in compariso

SUBMITTER: Adeyemo A 

PROVIDER: S-EPMC3573912 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature