Systematic review with meta-analysis of the epidemiological evidence relating FEV1 decline to lung cancer risk.

ABSTRACT:

Background

Reduced FEV1 is known to predict increased lung cancer risk, but previous reviews are limited. To quantify this relationship more precisely, and study heterogeneity, we derived estimates of β for the relationship RR(diff) = exp(βdiff), where diff is the reduction in FEV1 expressed as a percentage of predicted (FEV1%P) and RR(diff) the associated relative risk. We used results reported directly as β, and as grouped levels of RR in terms of FEV1%P and of associated measures (e.g. FEV1/FVC).

Methods

Papers describing cohort studies involving at least three years follow-up which recorded FEV1 at baseline and presented results relating lung cancer to FEV1 or associated measures were sought from Medline and other sources. Data were recorded on study design and quality a

SUBMITTER: Fry JS 

PROVIDER: S-EPMC3573968 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature