A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation.

ABSTRACT:

Background

Global demographic changes have stimulated marked interest in the process of aging. There has been, and will continue to be, an unrelenting rise in the number of the oldest old ( >85 years of age). Together with an ageing population there comes an increase in the prevalence of age related disease. Of the diseases of ageing, cardiovascular disease (CVD) has by far the highest prevalence. It is regarded that a finely tuned lipid profile may help to prevent CVD as there is a long established relationship between alterations to lipid metabolism and CVD risk. In fact elevated plasma cholesterol, particularly Low Density Lipoprotein Cholesterol (LDL-C) has consistently stood out as a risk factor for having a cardiovascular event. Moreover it is widely acknowledged that LDL-C m

SUBMITTER: Mc Auley MT 

PROVIDER: S-EPMC3574035 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature