Developing genetic epidemiological models to predict risk for nasopharyngeal carcinoma in high-risk population of China.

ABSTRACT: To date, the only established model for assessing risk for nasopharyngeal carcinoma (NPC) relies on the sero-status of the Epstein-Barr virus (EBV). By contrast, the risk assessment models proposed here include environmental risk factors, family history of NPC, and information on genetic variants. The models were developed using epidemiological and genetic data from a large case-control study, which included 1,387 subjects with NPC and 1,459 controls of Cantonese origin. The predictive accuracy of the models were then assessed by calculating the area under the receiver-operating characteristic curves (AUC). To compare the discriminatory improvement of models with and without genetic information, we estimated the net reclassification improvement (NRI) and integrated discrimination index (ID

SUBMITTER: Ruan HL 

PROVIDER: S-EPMC3574061 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature