Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering.

ABSTRACT: We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the millisecond time scale.

SUBMITTER: Asiala SM 

PROVIDER: S-EPMC3574179 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature