Global quantitative assessment of the colorectal polyp burden in familial adenomatous polyposis by using a web-based tool.

ABSTRACT:

Background

Accurate measures of the total polyp burden in familial adenomatous polyposis (FAP) are lacking. Current assessment tools include polyp quantitation in limited-field photographs and qualitative total colorectal polyp burden by video.

Objective

To develop global quantitative tools of the FAP colorectal adenoma burden.

Design

A single-arm, phase II trial.

Patients

Twenty-seven patients with FAP.

Intervention

Treatment with celecoxib for 6 months, with before-treatment and after-treatment videos posted to an intranet with an interactive site for scoring.

Main outcome measurements

Global adenoma counts and sizes (grouped into categories: <2 mm, 2-4 mm, and >4 mm) were scored from videos by using a novel Web-based tool. Baseline and end-of-s

SUBMITTER: Lynch PM 

PROVIDER: S-EPMC3574220 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature