Dataset Information

The long-term effectiveness of a lifestyle intervention in severely obese individuals.

ABSTRACT:

Objective

Severe obesity (body mass index [BMI] ≥40 kg/m(2)) is a serious public health concern. Although bariatric surgery is an efficacious treatment approach, it is limited in reach; thus, nonsurgical treatment alternatives are needed. We examined the 4-year effects of an intensive lifestyle intervention on body weight and cardiovascular disease risk factors among severely obese, compared with overweight (25 ≤BMI <30), class I (30 ≤BMI <35), and class II obese (35 ≤BMI <40) participants.

Methods

There were 5145 individuals with type 2 diabetes (45-76 years, BMI ≥25 kg/m(2)) randomized to an intensive lifestyle intervention or diabetes support and education. The lifestyle intervention group received a behavioral weight loss program that included group and individual meetings, a ≥10% weight loss goal, calorie restriction, and increased physical activity. Diabetes support and education received a less intense educational intervention. Four-year changes in body weight and cardiovascular disease risk factors were assessed.

Results

Across BMI categories, 4-year changes in body weight were significantly greater in lifestyle participants compared with diabetes support and education (Ps <.05). At year 4, severely obese lifestyle participants lost 4.9%±8.5%, which was similar to class I (4.8%±7.2%) and class II obese participants (4.4%±7.6%), and significantly greater than overweight participants (3.4%±7.0%; P <.05). Four-year changes in low-density-lipoprotein cholesterol, triglycerides, diastolic blood pressure, HbA(1c), and blood glucose were similar across BMI categories in lifestyle participants; however, the severely obese had less favorable improvements in high-density-lipoprotein cholesterol (3.1±0.4 mg/dL) and systolic blood pressure (-1.4±0.7 mm Hg) compared with the less obese (Ps <.05).

Conclusion

Lifestyle interventions can result in important long-term weight losses and improvements in cardiovascular disease risk factors among a significant proportion of severely obese individuals.

SUBMITTER: Unick JL

PROVIDER: S-EPMC3574274 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Publications

The long-term effectiveness of a lifestyle intervention in severely obese individuals.

Unick Jessica L JL Beavers Daniel D Bond Dale S DS Clark Jeanne M JM Jakicic John M JM Kitabchi Abbas E AE Knowler William C WC Wadden Thomas A TA Wagenknecht Lynne E LE Wing Rena R RR

The American journal of medicine 20130301 3

<h4>Objective</h4>Severe obesity (body mass index [BMI] ≥40 kg/m(2)) is a serious public health concern. Although bariatric surgery is an efficacious treatment approach, it is limited in reach; thus, nonsurgical treatment alternatives are needed. We examined the 4-year effects of an intensive lifestyle intervention on body weight and cardiovascular disease risk factors among severely obese, compared with overweight (25 ≤BMI <30), class I (30 ≤BMI <35), and class II obese (35 ≤BMI <40) participan ...[more]

PMID: 23410564

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Dataset Information

The long-term effectiveness of a lifestyle intervention in severely obese individuals.

Objective

Methods

Results

Conclusion

Publications

The long-term effectiveness of a lifestyle intervention in severely obese individuals.

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