Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis.

ABSTRACT:

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Background

A giant congenital melanocytic nevus (GCMN) is a malformation of the pigment cells. It is a distress to the patients for two reasons: one is disfigurement, and the other is the possibility of malignant changes. However, the underlying mechanisms of the development of GCMN and melanotumorigenesis in GCMN are unknown. Hence, the aim of this study was to identify the proteomic alterations and associated functional pathways in GCMN.

Results

Proteomic differences between GCMN (n = 3) and normal skin samples (n = 3) were analyzed by one-dimensional-liquid chromatography-tandem mass spectrometry Relative levels of the selected proteins were validated using western blot analysis. The biological processes associated with the abundance modified proteins w

SUBMITTER: Kim HK 

PROVIDER: S-EPMC3575290 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature