MHC class II DQB diversity in the Japanese black bear, Ursus thibetanus japonicus.

ABSTRACT:

Background

The major histocompatibility complex (MHC) genes are one of the most important genetic systems in the vertebrate immune response. The diversity of MHC genes may directly influence the survival of individuals against infectious disease. However, there has been no investigation of MHC diversity in the Asiatic black bear (Ursus thibetanus). Here, we analyzed 270-bp nucleotide sequences of the entire exon 2 region of the MHC DQB gene by using 188 samples from the Japanese black bear (Ursus thibetanus japonicus) from 12 local populations.

Results

Among 185 of 188 samples, we identified 44 MHC variants that encoded 31 different amino acid sequences (allotypes) and one putative pseudogene. The phylogenetic analysis suggests that MHC variants detected from the Japanese bl

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC3575356 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature