Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis.

ABSTRACT:

Unlabelled

Hepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk factors and genetic alterations. In Italy, particularly Southern Italy, chronic hepatitis C virus (HCV) infection represents the main cause of HCC. Using high-density oligoarrays, we identified consistent differences in gene-expression between HCC and normal liver tissue. Expression patterns in HCC were also readily distinguishable from those associated with liver metastases. To characterize molecular events relevant to hepatocarcinogenesis and identify biomarkers for early HCC detection, gene expression profiling of 71 liver biopsies from HCV-related primary HCC and corresponding HCV-positive non-HCC hepatic tissue, as well as gastrointestinal liver metastases paired with the appare

SUBMITTER: De Giorgi V 

PROVIDER: S-EPMC3575468 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature