Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.

ABSTRACT:

Background and purpose

Betahistine, the main histamine drug prescribed to treat vestibular disorders, is a histamine H(3) receptor antagonist. Here, we explored the potential for modulation of the most recently cloned histamine receptor (H(4) receptor) to influence vestibular system function, using a selective H(4) receptor antagonist JNJ 7777120 and the derivate compound JNJ 10191584.

Experimental approach

RT-PCR was used to assess the presence of H(4) receptors in rat primary vestibular neurons. In vitro electrophysiological recordings and in vivo behavioural approaches using specific antagonists were employed to examine the effect of H(4) receptor modulation in the rat vestibular system.

Key results

The transcripts of H(4) and H(3) receptors were present in rat ves

SUBMITTER: Desmadryl G 

PROVIDER: S-EPMC3575788 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature