A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes.

ABSTRACT: The transition of mammalian cells from quiescence to proliferation is accompanied by the differential expression of several microRNAs (miRNAs) and transcription factors. However, the interplay between transcription factors and miRNAs in modulating gene regulatory networks involved in human cell proliferation is largely unknown. Here we show that the miRNA miR-22 promotes proliferation in primary human cells, and through a combination of Argonaute-2 immunoprecipitation and reporter assays, we identified multiple novel targets of miR-22, including several cell-cycle arrest genes that mediate the effects of the tumor-suppressor p53. In addition, we found that miR-22 suppresses interferon gene expression by directly targeting high mobility group box-1 and interferon regulatory factor (IRF)-5,

SUBMITTER: Polioudakis D 

PROVIDER: S-EPMC3575845 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature