Principal components of heritability from neurocognitive domains differ between families with schizophrenia and control subjects.

ABSTRACT:

Objective

Various measures of neurocognitive function show mean differences among individuals with schizophrenia (SZ), their relatives, and population controls. We use eigenvector transformations that maximize heritability of multiple neurocognitive measures, namely principal components of heritability (PCH), and evaluate how they distribute in SZ families and controls.

Methods

African-Americans with SZ or schizoaffective disorder (SZA) (n = 514), their relatives (n = 1092), and adult controls (n = 300) completed diagnostic interviews and computerized neurocognitive tests. PCH were estimated from 9 neurocognitive domains. Three PCH, PCH1-PCH3, were modeled to determine if status (SZ, relative, and control), other psychiatric covariates, and education were significant predict

SUBMITTER: Wiener H 

PROVIDER: S-EPMC3576168 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature