Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium.

ABSTRACT:

Objective

To determine whether benzodiazepine and propofol doses are increased at night and whether daytime and nighttime sedative doses are associated with delirium, coma, and delayed liberation from mechanical ventilation.

Design

Single-center, prospective cohort study nested within the Awakening and Breathing Controlled randomized trial.

Setting

Saint Thomas Hospital in Nashville, TN, from 2004 to 2006.

Patients

Adult patients receiving mechanical ventilation for >12 hrs with continuous recording of hourly sedation dosing.

Interventions

We measured hourly doses of benzodiazepine and propofol exposure during the daytime (7 AM to 11 PM) and nighttime (11 PM to 7 AM) for 5 days. We quantified nighttime dose increases by subtracting the average hourly day

SUBMITTER: Seymour CW 

PROVIDER: S-EPMC3576216 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature