Unique small RNA signatures uncovered in the tammar wallaby genome.

ABSTRACT:

Background

Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. The tammar wallaby, a marsupial mammal, is a powerful comparative model for studying the evolution of regulatory networks. As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs).

Results

Using next generation sequencing, we have characterized the major classes of sm

SUBMITTER: Lindsay J 

PROVIDER: S-EPMC3576234 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature