Predicting the binding patterns of hub proteins: a study using yeast protein interaction networks.

ABSTRACT:

Background

Protein-protein interactions are critical to elucidating the role played by individual proteins in important biological pathways. Of particular interest are hub proteins that can interact with large numbers of partners and often play essential roles in cellular control. Depending on the number of binding sites, protein hubs can be classified at a structural level as singlish-interface hubs (SIH) with one or two binding sites, or multiple-interface hubs (MIH) with three or more binding sites. In terms of kinetics, hub proteins can be classified as date hubs (i.e., interact with different partners at different times or locations) or party hubs (i.e., simultaneously interact with multiple partners).

Methodology

Our approach works in 3 phases: Phase I classifies if a

SUBMITTER: Andorf CM 

PROVIDER: S-EPMC3576370 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature