Four pillars of the S-phase checkpoint.

ABSTRACT: The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue of Genes & Development, Kumar and Burgers (pp. 313-321) report that Ddc1, Dpb11, and Dna2 function in concert to activate Mec1 during S phase of the cell cycle. Furthermore, the Tel1 kinase also contributes to the DDR in S phase when Mec1 activation is compromised.

SUBMITTER: Zou L 

PROVIDER: S-EPMC3576509 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature