Two-marker association tests yield new disease associations for coronary artery disease and hypertension.

ABSTRACT: It has been postulated that multiple-marker methods may have added ability, over single-marker methods, to detect genetic variants associated with disease. The Wellcome Trust Case Control Consortium (WTCCC) provided the first successful large genome-wide association studies (GWAS) which included single-marker association analyses for seven common complex diseases. Of those signals detected, only one was associated with coronary artery disease (CAD), and none were identified for hypertension (HTN). Our objective was to find additional genetic associations and pathways for cardiovascular disease by examining the WTCCC data for variants associated with CAD and HTN using two-marker testing methods. We applied two-marker association testing to the WTCCC dataset, which includes ~2,000 affected i

SUBMITTER: Slavin TP 

PROVIDER: S-EPMC3576836 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature