Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study.

ABSTRACT:

Aims

Atrial fibrillation (AF) is a frequent co-morbidity in heart failure (HF) associated with increased mortality, but little is known about the mechanisms underlying AF onset in HF patients. We evaluated the association of cardiovascular and genetic risk factors with AF in HF patients.

Methods and results

Individuals hospitalized for HF (n = 1040; 500 with AF) were identified from a large, population-based cohort study (n = 30 447; 2339 with AF). Genetic polymorphisms in the chromosomal regions 4q25 (rs2200733) and 16q22 (rs2106261) associated with AF in genome-wide association studies were genotyped. Association of cardiovascular risk factors and polymorphisms with AF was tested in HF patients and the entire cohort using both prospective and non-time-dependent models. Car

SUBMITTER: Smith JG 

PROVIDER: S-EPMC3576900 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature