Estimating the long term impact of kidney donation on life expectancy and end stage renal disease.

ABSTRACT:

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Background

Long term studies of live kidney donation do not show evidence of appreciable risks to the donor. However nephrectomy reduces total glomerular filtration rates (GFR) and is associated with increased rates of proteinuria and possibly hypertension. It is not clear to what extent these changes are associated with reduced life expectancy (LE) or increased risk of end stage renal disease (ESRD) since follow up is incomplete in most reports.

Methods

In a computer simulation model based on a US population chronic kidney disease model, increased hazard rates for higher blood pressure, proteinuria and low GFR were applied to healthy individuals undergoing donor nephrectomy. Subsequent LE and cumulative risk of ESRD were calculated.

Results

Kidney

SUBMITTER: Kiberd BA 

PROVIDER: S-EPMC3577426 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature