Prediction of vitamin interacting residues in a vitamin binding protein using evolutionary information.

ABSTRACT:

Background

The vitamins are important cofactors in various enzymatic-reactions. In past, many inhibitors have been designed against vitamin binding pockets in order to inhibit vitamin-protein interactions. Thus, it is important to identify vitamin interacting residues in a protein. It is possible to detect vitamin-binding pockets on a protein, if its tertiary structure is known. Unfortunately tertiary structures of limited proteins are available. Therefore, it is important to develop in-silico models for predicting vitamin interacting residues in protein from its primary structure.

Results

In this study, first we compared protein-interacting residues of vitamins with other ligands using Two Sample Logo (TSL). It was observed that ATP, GTP, NAD, FAD and mannose preferred {G,R

SUBMITTER: Panwar B 

PROVIDER: S-EPMC3577447 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature