Emergence of new lineage of Dengue virus 3 (genotype III) in Lucknow, India.

ABSTRACT:

Background and objectives

Dengue has re-emerged as an important arboviral disease causing significant morbidity. It has become hyperendemic in the Indian subcontinent with all four known dengue serotypes circulating.

Materials and methods

Multiple sequence alignments and phylogenetic trees of DENV-3 were constructed to determine the extent of the isolated dengue virus genetic heterogeneity and phylogeny.

Results

Sequencing and phylogenetic analysis of the C-prM gene junction revealed an active circulation of a new lineage of DENV-3 (genotype III) in this region of India.

Conclusion

Continuous epidemiological surveillance to monitor the incursion and spread of dengue virus genotypes in this region of India is needed.

SUBMITTER: Tripathi SK 

PROVIDER: S-EPMC3577557 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature