The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population.

ABSTRACT:

Background

Emerging evidence has shown that microRNAs (miRNAs) participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) located in the miRNAs may influence the function of mature miRNAs and then affect the processing of carcinogenesis. It has been suggested that two common SNPs rs2910164 in miR-146a and rs3746444 in miR-499 are associated with susceptibility to hepatocellular carcinoma (HCC). However, published results are inconsistent and inconclusive. To acquire a more precise effect of the association between these polymorphisms and HCC risk, we performed this meta-analysis.

Methodology/principal findings

We have conducted a search of case-control studies on the associations of SNPs rs2910164 and/or rs3746444 with suscept

SUBMITTER: Hu M 

PROVIDER: S-EPMC3577770 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature