Decisions during negatively-framed messages yield smaller risk-aversion-related brain activation in substance-dependent individuals.

ABSTRACT: A sizable segment of addiction research investigates the effects of persuasive message appeals on risky and deleterious behaviors. However, to date, little research has examined how various forms of message framing and corresponding behavioral choices might by mediated by risk-related brain regions. Using event-related functional MRI, we investigated brain regions hypothesized to mediate the influence of message appeals on decision making in substance-dependent (SD) compared with nonsubstance-dependent (non-SD) individuals. The Iowa Gambling Task (IGT) was modified to include positively-framed, negatively-framed, and control messages about long-term deck payoffs. In the positively-framed condition, the SD and non-SD groups showed improved decision-making performance that corresponded to hi

SUBMITTER: Fukunaga R 

PROVIDER: S-EPMC3577955 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature