Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus.

ABSTRACT:

Background

The presence and severity of coronary artery calcified plaque (CAC) differs markedly between individuals of African and European descent, suggesting that admixture mapping may be informative for identifying genetic variants associated with subclinical cardiovascular disease.

Methods and results

Admixture mapping of CAC was performed in 1040 unrelated African Americans with type 2 diabetes mellitus from the African American-Diabetes Heart Study, Multi-Ethnic Study of Atherosclerosis and Family Heart Study using the Illumina custom ancestry informative marker panel. All cohorts obtained computed tomography scanning of the coronary arteries using identical protocols. For each ancestry informative marker, the probability of inheriting 0, 1, and 2 copies of a European-

SUBMITTER: Divers J 

PROVIDER: S-EPMC3578054 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature